Mulholland drive is a perfect bridge between 'plottier' Lynch, and then the fucking crazy stuff (Inland Empire, The Return). So if you liked S3 of TP you will like Mulholland Drive! Perfect companion piece with Lost Highway.
It's pretty and well made. But none of the characters have ANY background or motivations. The closest we get is Richard Jenkins and he's not even in it much. Everyone else is a complete cipher. I also didn't appreciate that Willem Dafoe is the only person who smiles in the movie.