Gadsby is a seasoned comic who didn't have much of a US presence before Nanette was released. It's an amazing special with a powerful message. It has been savaged by lots of folks suffering from male fragility, mostly under the pretense that the special is "not actual stand-up." That's a valid observation of the work, but not a valid criticism of it, IMO. It's probably more akin to the type of one-person shows that Mike Birbiglia has been touring over the last several years: comedy presented as stand-up, but with a throughline that elevates it to something else.
This is a case where the audience score reflects angry backlash to a different perspective. That number is garbage. She's great and you should watch it, and then you should watch her new special that just dropped on Netflix too. It's quite different in tone, but still good.