When I'm actively listening to a record it doesn't bother me. When I'm doing more than just listening (say I'm cooking, because then I have to wash my hands too), it gets annoying and I dislike having to flip more often.
If given the choice between high end 33 and high end 45, like with some of the AP and MM titles, I always pick 33. I know it theoretically opens up the sound some, but between my system (which is good, but not exceptional) and my ears (which went to too many loud concerts in my 20s and have worked in a woodshop too long), I likely can't tell the difference sonically between 33 and 45 anyways.