COVID-19, hypertension and hypertension medication (ACE inhibitors and ARBs)
I've been reading a lot about a possible link between ACE inhibitors and hypertension with COVID-19. I've been taking one such medication for many years and my pressure had been beautiful for a while. Nevertheless, the reports coming out a few weeks ago, all of which were just theoretical, were concerning.
ACE inhibitors control hypertention by inhibiting ACE1, which converts angiotensin I into angiotensin II. ARBs are another class of hypertension drugs that affect the same pathway but by inhibiting the angiotensin receptor. They don't act on ACE2 directly. As some of you may know, SARS-CoV-2 enters human cells by binding to ACE2. The theory was that ACE inhibitors, ARBs and possibly hypertension in general, cause an increase in cellular levels of ACE2 indirectly and therefore help SARS-CoV-2 infection. None of this was proven, but it caused a shitstorm with lots of patients calling their doctors. I did a lot of reading myself. Recommendations were to not change anything because the danger of stopping those meds is great and changing them once you find one that works can take a lot of time for a doctor and a patient (and you want to avoid diverting doctor resources right now for a hypothetical).
Turns out, the opposite may be true. This was another theory floating around at the time and may actually be panning out, to my relief. ACE Inhibitors and ARBs may actually be protecting against SARS-CoV-2. Recent studies in cells in two separate labs are confirming this.
Anyway, this is ongoing and who knows where it will lead. Thought I'd share in case there are others here taking those medications and wanting more information.
If any of you have more information or wish to clarify anything here, please share.
For interest's sake, here is the biochemical pathway in question:
There is little evidence that antihypertensive drugs worsen COVID-19, and scientists are instead exploring the idea that such medications—or their downstream effects—may actually alleviate symptoms.
www.the-scientist.com
Contrairement aux informations qui ont circulé au cours des derniers jours, aucune preuve scientifique solide ne démontre que les médicaments contre l’hypertension puissent augmenter le risque d’une infection par le SRAS-CoV-2 ou en intensifier les symptômes, ont expliqué des chercheurs au...
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