Neverending Covid-19 Coronavirus

Vaccine experts are coming out against booster shots for the general population (healthy people). This is a meta-analysis on why they decided that a booster is not needed at this time.

Current evidence does not, therefore, appear to show a need for boosting in the general population, in which efficacy against severe disease remains high. Even if humoral immunity appears to wane, reductions in neutralising antibody titre do not necessarily predict reductions in vaccine efficacy over time, and reductions in vaccine efficacy against mild disease do not necessarily predict reductions in the (typically higher) efficacy against severe disease. This effect could be because protection against severe disease is mediated not only by antibody responses, which might be relatively short lived for some vaccines, but also by memory responses and cell-mediated immunity, which are generally longer lived.
The ability of vaccines that present the antigens of earlier phases of the pandemic (rather than variant-specific antigens) to elicit humoral immune responses against currently circulating variants indicates that these variants have not yet evolved to the point at which they are likely to escape the memory immune responses induced by those vaccines. Even without any changes in vaccine efficacy, increasing success in delivering vaccines to large populations will inevitably lead to increasing numbers of breakthrough cases, especially if vaccination leads to behavioural changes in vaccinees.


Booster shots also allow us to distract from how unbelievably selfish the west is being in not providing more vaccines to the third world. Can spin it as looking after people instead.
 
Booster shots also allow us to distract from how unbelievably selfish the west is being in not providing more vaccines to the third world. Can spin it as looking after people instead.
1000% agree.
We just need a patent waiver, but that would mean tons of money would not go to the undeserving pharmaceutical companies for taking publicly funded science and doing the simple job of applying it.
 


Massachusetts Governor Charlie Baker has activated the National Guard to drive school buses.

There is a huge shortage of school bus drivers nationwide right now, many of which are older and retired during the pandemic. The biggest issue with getting students back in the classroom is well, getting them there.
 


Massachusetts Governor Charlie Baker has activated the National Guard to drive school buses.

There is a huge shortage of school bus drivers nationwide right now, many of which are older and retired during the pandemic. The biggest issue with getting students back in the classroom is well, getting them there.

I read about this.
I think this is going to happen more often as older people who were able to buy houses at reasonable prices retire. Finding replacements for a job that doesn't pay more than $50K in MA is not feasible--someone would have to commute in from somewhere else. In my community, there are still reasonably priced homes, but there's no way you could secure financing unless you had a job where you were paid more. In the town over, where my parents live, house prices are astronomical and people commute from here, as well as from parts of Mississippi and extremely rural parts of Louisiana. People are driving 45 miles one way to work in a grocery store. These are "essential jobs" that are needed but due to really terrible pay and house unaffordability, most of these people cannot live in the communities where they work. Right now, you're seeing problems in MA because that's where housing has become most unaffordable.
 
Vaccine experts are coming out against booster shots for the general population (healthy people). This is a meta-analysis on why they decided that a booster is not needed at this time.

Current evidence does not, therefore, appear to show a need for boosting in the general population, in which efficacy against severe disease remains high. Even if humoral immunity appears to wane, reductions in neutralising antibody titre do not necessarily predict reductions in vaccine efficacy over time, and reductions in vaccine efficacy against mild disease do not necessarily predict reductions in the (typically higher) efficacy against severe disease. This effect could be because protection against severe disease is mediated not only by antibody responses, which might be relatively short lived for some vaccines, but also by memory responses and cell-mediated immunity, which are generally longer lived.
The ability of vaccines that present the antigens of earlier phases of the pandemic (rather than variant-specific antigens) to elicit humoral immune responses against currently circulating variants indicates that these variants have not yet evolved to the point at which they are likely to escape the memory immune responses induced by those vaccines. Even without any changes in vaccine efficacy, increasing success in delivering vaccines to large populations will inevitably lead to increasing numbers of breakthrough cases, especially if vaccination leads to behavioural changes in vaccinees.


I know it's just anectotal, but the current data here for the last 24 hours, with delta raging, has 202 infected with double doses, 63 with one and 572 wit none. When normalized for vaccination rates, this gives an infection rate of 2.14/100k for double, 11.00/100k for single and 18.05/100k for none. So 2 of every 31 cases per 100k is in double dosed people here, as of today.

In terms of vaccine efficiency, if I'm doing this right, this still translates to a 95% double dose efficiency of diagnosed cases, which frankly remains staggeringly great. Mind you, I'm not doing a comparison to placebo, so this is not really valid, but the numbers are pretty strong. A booster is not required yet for sure.
 
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:cry: :cry: :cry: :cry: :cry: :mad: :mad: :mad: :mad: :mad: :mad:

People suck
This is going to become a common occurrence across the country, wait and see. Again, COVID has been a pain beyond just the disease part of it, our previous leader gave every whack-a-do license to bring out their inner asshole whenever and wherever...............MERICA!
 
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A decent news report relating to the misunderstanding and wrong conclusions being drawn from the use of the expression "waning immunity".

 

The Yelp page for this bar with the No Mask Policy is making me chuckle this morning. Love the Q&A.
 

For those who said Covid is not that bad. Well... It just surpassed the 1918 Spanish Flu pandemic in total deaths.
 

For those who said Covid is not that bad. Well... It just surpassed the 1918 Spanish Flu pandemic in total deaths.

So is the "it's just like the flu" narrative going to end?

(rhetorical question... of course not.)
 
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